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This system involved the administration of anabolic steroids on rats, either orally or by injection (depending on the anabolic steroid being assessed)beginning at 1 week of age," said Vestergaard. "By 7 weeks on average, we had the rats in training condition that were no longer receiving injections. At 6 weeks of age, the rats had been given all the drugs in the system. The anabolic steroid regimen had a clear effect on learning performance and the ability to learn new task information." The same group of adult male rats were then returned to their home cages with their original treatment regimen. During this time, researchers compared and contrasted both the rats in training condition and the control rats. "In the training rats, we observed reduced latency in the first trial, and increased latency in the middle trial when all injections were replaced with non-drug placebo," said Vestergaard. "The non-drug placebo also had no effect. However, the anabolic steroid regimen decreased latency to the second trial of memory, and increased latency in the final trial of learning. This was true whether the rats were given the placebo or the anabolic steroid. We also saw no effect on recall." The next step for researchers is assessing an additional group of young, cognitively intact rats. The researchers hope to discover whether the anabolic steroid protocol can provide an effective, non-addictive and non-invasive means of enhancing memory for young, healthy people. In addition to Vestergaard, this research has been supported by grants from the U.S. Department of Veterans Affairs (AR02-24004), the U.S. Army Research Institute of Environmental Medicine (R01EB008025) and the Canadian Institutes of Health Research (IRB 0622-2-08-1). Source: University at Buffalo Acetylation of DNA and the Origin of Modern Life Related Article:

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